abstract：:Mitochondrial DNA (mtDNA) abnormalities with primary pathogenic significance for optic nerve atrophy have been detected in inflammatory demyelinating conditions indistinguishable from multiple sclerosis (MS). However, the degree of involvement of mtDNA alterations in the pathogenesis of MS is not clear. To further cla...

journal_title：Journal of the neurological sciences

authors： Kalman B,Lublin FD,Alder H

更新日期：1996-09-01 00:00:00

abstract：:We report a 67-year-old man who developed yes/yes head tremor without appendicular tremor six weeks after right occipital and bilateral cerebellar infarction. The tremor was resting-postural. Its activity increased with excitement, decreased either after ethanol, lateroflexion or rest and stopped at sleep. Four-vessel...

journal_title：Journal of the neurological sciences

authors： Finsterer J,Muellbacher W,Mamoli B

更新日期：1996-08-01 00:00:00

abstract：:The mechanisms primarily responsible for the degenerative processes occurring in dystrophic skeletal muscle remain unresolved. The identification of the mechanisms that lead to the complete sparing of extraocular muscle in dystrophinopathies is of particular interest. A number of studies have provided evidence to sugg...

journal_title：Journal of the neurological sciences

authors： Ragusa RJ,Chow CK,St Clair DK,Porter JD

更新日期：1996-08-01 00:00:00

abstract：:Respiratory failure accounts for the majority of deaths in amyotrophic lateral sclerosis (ALS) but only rarely is ALS diagnosed on the basis of respiratory insufficiency. We report four ALS patients presenting with acute respiratory failure. In three patients we have performed EMG needle examination of both hemidiaphr...

journal_title：Journal of the neurological sciences

authors： de Carvalho M,Matias T,Coelho F,Evangelista T,Pinto A,Luís ML

更新日期：1996-08-01 00:00:00

abstract：:The phase of rapid reduction of isometric strength in single muscle groups was identified and its slope was calculated in patients studied with the TQNE method. This parameter was studied in the extremities and in respiration in 4 ALS patients and 4 PMA (progressive spinal muscle atrophy) patients. The slopes of the s...

journal_title：Journal of the neurological sciences

authors： Conradi S,Ronnevi LO

更新日期：1996-08-01 00:00:00

abstract：:Cortical excitability to magnetic stimulation was investigated interictally in 10 patients with migraine with aura, 10 with migraine without aura and in 10 healthy volunteers. Thresholds, latencies and amplitudes of the magnetic-evoked potentials (MEPs) were measured from threshold to 100% stimulus intensity in 10% st...

journal_title：Journal of the neurological sciences

authors： van der Kamp W,Maassen VanDenBrink A,Ferrari MD,van Dijk JG

更新日期：1996-07-01 00:00:00

abstract：:To improve the understanding of neuronal cell swelling in cerebral ischemia, cell volume regulation, viability, intracellular electrolytes, and lactate production of Neuro-2A neuroblastoma cells were studied using an in vitro model. The volume regulatory capacity of Neuro-2A cells was assessed after incubation in hypo...

journal_title：Journal of the neurological sciences

authors： Mackert BM,Staub F,Peters J,Baethmann A,Kempski O

更新日期：1996-07-01 00:00:00

abstract：:Intellectual problems are a recognized feature of neurofibromatosis 1 (NF1) but their aetiology is unknown. We investigated the frequency, nature, severity and cause of intellectual impairment in NF1. We undertook neurological and psychometric assessments on 103 patients with NF1 and 105 controls equated for age, sex ...

journal_title：Journal of the neurological sciences

authors： Ferner RE,Hughes RA,Weinman J

更新日期：1996-06-01 00:00:00

abstract：:Whether the primary mechanisms of migraine are vascular or neurogenic is, as yet, unresolved. In humans it is still unclear whether sumatriptan acts via constriction of dilated arteries or through other mechanisms. Doppler sonography is a non-invasive method for measuring blood flow velocities (BFV), an indirect marke...

journal_title：Journal of the neurological sciences

authors： Limmroth V,May A,Auerbach P,Wosnitza G,Eppe T,Diener HC

更新日期：1996-06-01 00:00:00

abstract：:Memantine, a clinically employed drug with N-methyl-D-aspartate (NMDA) receptor antagonistic effects, dose-dependently ameliorates neurological deficits in Lewis rat experimental autoimmune encephalomyelitis (EAE). Interestingly, this therapeutic effect was not due to dampened CNS inflammation, as assessed by immunohi...

journal_title：Journal of the neurological sciences

authors： Wallström E,Diener P,Ljungdahl A,Khademi M,Nilsson CG,Olsson T

更新日期：1996-05-01 00:00:00

abstract：:The primary objective of this study was to attempt to induce excessive intraglial acidosis during ischemia by subjecting rats to an initial insult which leads to post insult accumulation of glycogen, presumed to accumulate primarily in astrocytes. The initial insults were 15 min of transient forebrain ischemia, 30 min...

journal_title：Journal of the neurological sciences

authors： Folbergrova J,Katsura KI,Siesjo BK

更新日期：1996-04-01 00:00:00

abstract：:We studied a 53-year-old woman with progressive weakness of the left arm, gradually spreading to the other limbs. Neurological examination revealed a motor neuron syndrome with paresis, fasciculations and atrophy. Electrophysiological studies showed multiple motor conduction blocks. The anti-GM1 IgM titer was elevated...

journal_title：Journal of the neurological sciences

authors： Veugelers B,Theys P,Lammens M,Van Hees J,Robberecht W

更新日期：1996-03-01 00:00:00

abstract：:The incidence of carpal tunnel syndrome is increased during pregnancy. The common conventional therapeutic approach is conservative, as symptoms usually abate after delivery. We describe our experience with 65 hands (50 patients), who were treated initially by a conservative approach and later, when required, surgical...

journal_title：Journal of the neurological sciences

authors： Stahl S,Blumenfeld Z,Yarnitsky D

更新日期：1996-03-01 00:00:00

abstract：:We performed a quantitative neuropathological investigation of senile plaques and neurofibrillary tangles in the brains of 14 Japanese patients with diffuse Lewy body disease (DLBD), and examined apolipoprotein E (APOE) gene polymorphism in these patients. Most DLBD brains had as many senile plaques as those with Alzh...

journal_title：Journal of the neurological sciences

authors： Kawanishi C,Suzuki K,Odawara T,Iseki E,Onishi H,Miyakawa T,Yamada Y,Kosaka K,Kondo N,Yamamoto T

更新日期：1996-03-01 00:00:00

abstract：:We followed two cohorts of Amyotrophic Lateral Sclerosis (ALS) patients to examine the survival and prognostic factors of ALS and the impact of selective referral on prognosis of ALS. The first cohort consisted of population-based incident ALS cases from Harris County, Texas, first diagnosed between 1985 and 1988. The...

journal_title：Journal of the neurological sciences

authors： Lee JR,Annegers JF,Appel SH

更新日期：1995-10-01 00:00:00

abstract：:We have investigated protein expression and genotype in 59 Becker muscular dystrophy (BMD) patients. The aim was to identify possible causes of the marked variability in phenotype in patients with similar deletions/mutations. The patients were examined neurologically and functionally and underwent Manual Muscle Testin...

journal_title：Journal of the neurological sciences

authors： Morandi L,Mora M,Confalonieri V,Barresi R,Di Blasi C,Brugnoni R,Bernasconi P,Mantegazza R,Dworzak F,Antozzi C

更新日期：1995-10-01 00:00:00

abstract：:Morphologic alterations in biopsies of central and peripheral nervous tissue were investigated at the light-and electron-microscopic level in the first cases of lysosomal alpha-N-acetylgalactosaminidase deficiency. Widespread spheroid formation was observed in terminal and preterminal axons. Neocortical and peripheral...

journal_title：Journal of the neurological sciences

authors： Wolfe DE,Schindler D,Desnick RJ

更新日期：1995-09-01 00:00:00

abstract：:The significance of P300 in investigation of the cognitive changes characteristic of aging and dementia is well established. But some controversies about sensitivity and specificity of P300 latency prolongation in detection of dementia still exist, and its predictive value and specificity in "real" clinical situations...

journal_title：Journal of the neurological sciences

authors： Filipović SR,Kostić VS

更新日期：1995-08-01 00:00:00

abstract：:Cathepsin B (CB) activity was measured in aqueous extracts of frozen autopsy specimens of centrum semiovale from three MS patients, five control patients with other neurological diseases, and five normal individuals. Mean activity was significantly increased in the MS tissue compared with controls. The mean activity i...

journal_title：Journal of the neurological sciences

authors： Bever CT Jr,Garver DW

更新日期：1995-07-01 00:00:00

abstract：:We report a new Japanese family of sialidosis type I. The sialidase activity was deficient in the lymphocytes of 2 patients (6.8% (sister) and 12.5% (brother) of control mean). However, surprisingly, using the transformed lymphocytes by EB virus, this activity was activated to 51.7% (sister) and 49.5% (brother) of con...

journal_title：Journal of the neurological sciences

authors： Yamamoto M,Yamauchi T,Yamamoto K,Kobayashi T

更新日期：1995-07-01 00:00:00

abstract：:Sensory ataxia in inorganic germanium intoxication is rare. A 63-year-old housewife had taken inorganic germanium preparations at a dosage of 36 mg a day for about 6 years (total dose about 80 g). She subsequently developed difficulty in writing and gait disturbance with peripheral neuropathy and renal involvement. Ge...

journal_title：Journal of the neurological sciences

authors： Asaka T,Nitta E,Makifuchi T,Shibazaki Y,Kitamura Y,Ohara H,Matsushita K,Takamori M,Takahashi Y,Genda A

更新日期：1995-06-01 00:00:00

abstract：:The production of interleukin-2 (IL-2) and interleukin-6 (IL-6) by peripheral blood mononuclear cells (MNC) was assessed in patients with Alzheimer's disease (AD) who were subdivided into two groups--mild and moderately-severe--according to the severity of the disease, probable vascular dementia (VaD) patients and eld...

journal_title：Journal of the neurological sciences

authors： Huberman M,Sredni B,Stern L,Kott E,Shalit F

更新日期：1995-06-01 00:00:00

abstract：:The levels of the neuroprotective excitatory amino acid receptor antagonist kynurenic acid (KYNA) have been previously shown to be reduced in several regions of the brain of Huntington's disease (HD) patients. Thus, KYNA has been speculatively linked to the pathogenesis of HD. We have examined KYNA levels and the acti...

journal_title：Journal of the neurological sciences

authors： Jauch D,Urbańska EM,Guidetti P,Bird ED,Vonsattel JP,Whetsell WO Jr,Schwarcz R

更新日期：1995-05-01 00:00:00

abstract：:Possible changes in brain metabolites in motor neurone disease/amytrophic lateral sclerosis (MND/ALS) were investigated using 1H magnetic resonance spectroscopy (MRS). A series of normal, healthy volunteer controls and MND patients have been studied using a spin echo (SE) 135 ms sequence, acquiring spectra from the re...

journal_title：Journal of the neurological sciences

authors： Jones AP,Gunawardena WJ,Coutinho CM,Gatt JA,Shaw IC,Mitchell JD

更新日期：1995-05-01 00:00:00

abstract：:Motor neurone disease (MND) is a useful paradigm for many progressive disabling neurological disorders and serves as a particularly opposite model for the study of patients' responses to progressive and irreversible disability. We studied the progression of disability and the patients' perception of their health in a ...

journal_title：Journal of the neurological sciences

authors： Young CA,Tedman BM,Williams IR

更新日期：1995-05-01 00:00:00

abstract：:Noninvasive ventilatory assistance, in ALS patients, with the bilevel intermittent positive air pressure (Bipap) was studied, in a prospective and controlled trial, by the authors. Twenty ALS bulbar patients, fulfilling El Escorial criteria for probable or definite disease, were selected. For the follow-up all patient...

journal_title：Journal of the neurological sciences

authors： Pinto AC,Evangelista T,Carvalho M,Alves MA,Sales Luís ML

更新日期：1995-05-01 00:00:00

abstract：:Sympathetic skin response (SSR) is a simple, reproducible test of function of a polysynaptic reflex having diverse afferents, a common efferent pathway through the spinal cord, pre and post-ganglionic sympathetic fibers and with sweat glands as effectors. The reflex is co-ordinated in the posterior hypothalamus or upp...

journal_title：Journal of the neurological sciences

authors： Arunodaya GR,Taly AB

更新日期：1995-04-01 00:00:00

abstract：:We report the clinical, neuroradiological and biochemical features of a patient with epilepsia partialis continua (EPC). MRI studies disclosed multiple cortico-subcortical areas of abnormal signal intensity. The activity of complex I of the mitochondrial respiratory chain was markedly reduced in skeletal muscle. The b...

journal_title：Journal of the neurological sciences

authors： Antozzi C,Franceschetti S,Filippini G,Barbiroli B,Savoiardo M,Fiacchino F,Rimoldi M,Lodi R,Zaniol P,Zeviani M

更新日期：1995-04-01 00:00:00

abstract：:On September 28, 1994, the investigators of the Asymptomatic Carotid Atherosclerosis Study (ACAS) reported the interim results of a randomized controlled clinical trial of carotid endarterectomy in patients who have asymptomatic carotid stenosis of greater than 60% reduction in diameter. In addition to aspirin and agg...

journal_title：Journal of the neurological sciences

authors：

更新日期：1995-03-01 00:00:00

abstract：:We present a patient with Parkinson's disease whose bilateral tremor transiently resolved after a unilateral left ventrolateral thalamotomy. The transient resolution of the bilateral tremor was associated with a focal thalamic lesion and a second lesion in the corpus callosum. The mechanism of this phenomenon may be r...

journal_title：Journal of the neurological sciences

authors： Greene KA,Wallace RC,Fram EK,Shetter AG,Lieberman AN

更新日期：1995-03-01 00:00:00

abstract：:The thyroid hormone thyroxine (T4), administered post-natally to neonatal rats, has been shown to accelerate development of auditory function, as expressed by auditory nerve-brainstem evoked responses. This study investigated whether this earlier development was also reflected in other sensory modalities. Rat pups wer...

journal_title：Journal of the neurological sciences

authors： Freeman S,Sohmer H

更新日期：1995-02-01 00:00:00

abstract：:The pathogenic mechanism underlying the vascular changes in Binswanger's encephalopathy (BE) is unknown. To test whether alterations of the humoral immunity may lead to endothelium damage, we analyzed serum levels of anti-brain endothelium antibodies (ABEA) (IgG and IgM) in 16 BE patients, 19 subjects with ischemic va...

journal_title：Journal of the neurological sciences

authors： Annunziata P,Cioni C,Moschini F,Riccucci A,Guazzi GC

更新日期：1995-01-01 00:00:00

abstract：:A study was made of Wistar rat soleus muscle following intraperitoneal administration of denervated muscle extract over 1 and 2 days. Light microscopy revealed the appearance on fiber surfaces of basophilic satellite structures whose histochemical behaviour differed from that of the parent fiber. Small fibers showing ...

journal_title：Journal of the neurological sciences

authors： Peña J,Jimena I,Luque E,Vaamonde R

更新日期：1995-01-01 00:00:00

abstract：:We have used a mouse model of herpes simplex encephalitis produced by intranasal inoculation of virus to study the expression of viral immediate early, early and late genes and latency associated transcript (LAT) in trigeminal ganglia and brain at various times after inoculation. A PCR technique was used to detect the...

journal_title：Journal of the neurological sciences

authors： Drummond CW,Eglin RP,Esiri MM

更新日期：1994-12-20 00:00:00

abstract：OBJECTIVE:To assess the temporal and spatial variation in length of hospital stay for cerebrovascular disease in the United States over three decades. DESIGN:Age-, region-, and stroke type-specific length-of-hospital-stay data for nearly 4 million patients admitted with cerebrovascular disease were obtained for the Pr...

journal_title：Journal of the neurological sciences

authors： Lanska DJ

更新日期：1994-12-20 00:00:00

abstract：:We detected androgen receptor (AR) mRNA expression in various tissues in the patients with X-BSNP and controls using reverse transcription polymerase chain reaction (RT-PCR) and Northern blot analysis. The AR mRNAs were expressed in a wide variety of tissues including the testis, scrotal skin, liver, skeletal and card...

journal_title：Journal of the neurological sciences

authors： Doyu M,Sobue G,Kimata K,Yamamoto K,Mitsuma T

更新日期：1994-12-01 00:00:00

abstract：:In order to investigate the expression of endothelin-like immunoreactivity in astrocytes of viral infections of the human brain the avidin-biotin peroxidase complex method and a polyclonal antiserum were used. Autopsy material was obtained from 5 cases of herpes simplex encephalitis, two of progressive multifocal leuk...

journal_title：Journal of the neurological sciences

authors： Ma KC,Nie XJ,Höög A,Olsson Y,Zhang WW

更新日期：1994-11-01 00:00:00

abstract：:We observed a stroke patient with an infarct of the internal capsule interrupting the pyramidal tract who stretched his hemiplegic arm during spontaneous and apomorphine-induced yawning. The putative mechanism by which yawning can induce the paradoxical motor response of the plegic arm in the patient might be the func...

journal_title：Journal of the neurological sciences

authors： Blin O,Rascol O,Azulay JP,Serratrice G,Nieoullon A

更新日期：1994-11-01 00:00:00

abstract：:We used the Computer Assisted Sensory Examination (CASE IV) and a new, rapid 4, 2, and 1 stepping algorithm to determine the influence of local temperature on vibratory detection threshold (VDT) in the great toe of 11 healthy adult subjects. We found that over a broad range of temperatures, VDT did not vary much. A la...

journal_title：Journal of the neurological sciences

authors： Thyagarajan D,Dyck PJ

更新日期：1994-11-01 00:00:00

abstract：:We examined 19 muscle biopsies from 14 patients with autosomal recessive distal muscular dystrophy (DisMD) histochemically and immunohistochemically to characterize the histologic features of this disease and to determine whether dystrophin and dystrophin-associated proteins (DAPs) are normally present in the muscles ...

journal_title：Journal of the neurological sciences

authors： Yamanouchi Y,Ozawa E,Nonaka I

更新日期：1994-10-01 00:00:00